Yes, you can wear travel support hose all day, and they're designed for extended use but it is not necessary to use it for whole day. These compression stockings help improve circulation, reduce swelling, and prevent blood clots during long periods of sitting or standing, making them ideal for travel. Just ensure you're wearing the correct size and comfort level. If you experience any discomfort or irritation, take breaks to remove them, but overall, they're safe for all-day wear.