Among the top hotels on Sanibel Island, Florida, Sundial Beach Resort & Spa stands out because of its beachfront location and family-friendly atmosphere, while Sanibel Island Beach Resort is the perfect choice if you want a more relaxed and intimate stay. Casa Ybel Resort offers large suites and breathtaking views of the Gulf, and Island Inn is the ideal choice if you want a quiet, historic property right on the beach. Ultimately, choosing the best one depends on whether you are looking for luxury, family amenities, or a peaceful escape.