The best place to stay in Key West depends on what kind of trip you want. If you love nightlife, entertainment, and walking distance to attractions, areas near Duval Street are ideal. Travelers seeking charm and history often choose Old Town for its classic architecture and cozy inns, while those wanting relaxation and ocean views prefer quieter beachside locations. Overall, central areas are best for first-time visitors because they provide easy access to sightseeing, dining, and sunset spots.