Put the optimum amount of items in each cube. If you under or overpack you'll be more likely to get creases in your clothing during transport. Arrange the packing cubes neatly into your luggage. Do this strategically so that you can properly optimise all the space in your bags.
Use packing cubes in a carry-on by grouping clothes by type or outfit, then tightly rolling or folding items to fit each cube. Stack cubes like Tetris to maximise space and keep your bag organised.