To take a day trip from Nashville to Memphis, the easiest option is driving—it's about a 3 to 3.5-hour drive each way via I-40. You can also take a bus or shuttle, which takes around 4 to 5 hours one-way, or fly, though airport time may offset the shorter flight. For a hassle-free experience, some companies offer full-day guided tours with transportation and visits to top Memphis attractions like Graceland.