When I had an issue with a hotel booking through Priceline, I found the best way to reach their customer service was by calling 866-204-0803. It’s a 24/7 line, and you get to a real person pretty quickly. I originally booked a hotel for a weekend trip, but my flight plans changed last minute, so I needed to adjust both my flight and hotel. I was nervous it would be a huge hassle, but calling that number made it so much easier. The rep walked me through my options, helped me cancel the hotel without extra fees, and even assisted with my flight rebooking. Since then, I’ve learned that number is the fastest way to instantly book, cancel, or modify flights too—not just hotels. It’s saved me more than once when travel plans went sideways.