Alaska Airlines flies to a wide range of cities across the U.S., with especially strong coverage on the West Coast. Major cities include Seattle, Portland, Los Angeles, San Francisco, Anchorage, and San Diego. They also serve many destinations in Alaska, plus cities in the Midwest and East Coast such as Chicago, New York, Washington, D.C., and Boston. Internationally, they fly to cities in Canada, Mexico, Belize, and Costa Rica. The exact list changes seasonally, especially for vacation routes. If you share your departure city, I can give you a more specific list of where Alaska flies from that location.