Basically, it all depends on what kind of holiday you want. However, some of the best vacation spots in the US that you shouldn't miss are Hawaii if you love beaches and nature, Las Vegas for fun and games, New York City for sightseeing and culture, Florida (Orlando/Miami) for theme parks and lovely beaches, California (LA, San Francisco, Yosemite) for a perfect combination of city life and nature, and Colorado if you love mountains and beautiful landscapes. People usually choose these places because most of the time, these destinations have the ingredients for a wonderful trip.